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Influenta dozelor subterapeutice a combinatiei de neomicina si oxitetraciclina asupra Salmonella typhimurium la porci, vitei si puii de gaina

Girard AE, English AR, Evangelisti DG, Lynch JE, Solomons IA.

     Dozele subterapeutice de oxitetraciclina si neomicina administrate in hrana animalelor nu au determinat o crestere a cantitatii, raspandirii sau a purtatorilor de S. typhimurium la purcei, vitei si puii de gaina. In general, medicatia reduce procentul animalelor purtatoare de S. typhimurium. Medicamentele au fost administrate in hrana animalelor incepand cu 5 zile inaintea inocularii orale cu S. typhimurium si a continuat inca 28 de zile dupa inoculare. S-au obtinut colonii de la toate cele 3 specii de animale care au evidentiat semnele clinice ale infectiei, colonii izolate din fecale. Doar la suine si doar la un singur caz a fost izolata o colonie rezistenta. Se poate trage concluzia ca nu exista dovezi care ar sugera continuarea hranirii cu doze scazute de oxitetraciclina si neomicina pe o perioada de 4 saptamani pentru a preveni o posibila crestere a frecventei bolilor la animale si a riscului transmiterii la oameni.

Antimicrob Agents Chemother. 1976 Jul;10(1):89-95




Influence of subtherapeutic levels of a combination of neomycin and oxytetracycline on Salmonella typhimurium in swine, calves, and chickens.

Girard AE, English AR, Evangelisti DG, Lynch JE, Solomons IA.

     Subtherapeutic levels of oxytetracycline plus neomycin in animal feeds did not bring about increases in the quantity, prevalence, or shedding of Salmonella typhimurium in swine, calves, or chickens. In fact, the medication generally reduced the proportion of animals carrying S. typhimurium. The medicated groups were fed rations containing oxytetracycline plus neomycin commencing 5 days prior to oral inoculation with S. typhimurium and continuing through a 28-day postinoculation period. Colonization of S. typhimurium occurred in all three animal species, as evidenced by clinical signs of infection and/or colony counts in feces. Only from swine and on only one occasion was a single resistant colony isolated. It is concluded that no evidence has been obtained which would implicate the continuous low-level feeding of oxytetracycline and neomycin for a 4-week period to a potential increased incidence of disease in animals or as a hazard to humans.

Antimicrob Agents Chemother. 1976 Jul;10(1):89-95


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