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Dispozitia cinetica a tilozinei administrata intravenos si intramuscular la porci

C. Prats1 , G. El Korchia 1, R. Francesch 2, M. Arboixa 1 and B. Péreza 1

1 Departament de Farmacologia, Terapèutica i Toxicologia, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
2 LABIANA Life Sciences, S.A., Terrassa, Spain
Received 22 February 2002. Available online 25 August 2002.

Dispozitia tilozinei a fost studiata folosind un experiment incrucisat, pe sase porci dupa administrarea intravenoasa si intramusculara a 10 mg/kg greutate corporala. Probele de plasma au fost analizate prin HPLC si prin detectia absorbtiei ultravioletelor. Dupa administrarea intravenoasa, t1/2β a fost de 271.3 min, Vd 14.6 L kg−1, Vss 9.7 L kg−1 si CL 26.8 mL min−1 kg−1. Dupa administrarea intramusculara, Cmax a fost de 1 μg mL−1 dupa 90 de minute de la administrare. Durata medie de absorbtie a fost de 1988.7 min si biodosponibilitatea de 95%.

Research in Veterinary Science
Volume 73, Issue 2, October 2002, Pages 141-144


Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs
C. Prats1 , G. El Korchia 1, R. Francesch 2, M. Arboixa 1 and B. Péreza 1

1 Departament de Farmacologia, Terapèutica i Toxicologia, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
2 LABIANA Life Sciences, S.A., Terrassa, Spain
Received 22 February 2002. Available online 25 August 2002.


The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg−1 b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t1/2β was 271.3 min, Vd 14.6 L kg−1, Vss 9.7 L kg−1 and CL 26.8 mL min−1 kg−1. After i.m. administration, a Cmax of 1 μg mL−1 was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%.

Research in Veterinary Science
Volume 73, Issue 2, October 2002, Pages 141-144

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